BCG Vaccine Trial Data

Results from 13 prospective clinical trials comparing tuberculosis rates among participants vaccinated with Bacillus Calmette-Guerin (BCG) and unvaccinated controls. The data are useful for univariate meta-analysis, meta-regression, residual diagnostics, publication-bias examples, and profile-likelihood examples in mars.

Usage

bcg

Format

A data frame with 13 rows and 11 columns:

trial

Trial identifier.

author

Study author label.

year

Publication year.

tpos

Number of tuberculosis cases in the vaccinated group.

tneg

Number without tuberculosis in the vaccinated group.

cpos

Number of tuberculosis cases in the control group.

cneg

Number without tuberculosis in the control group.

ablat

Absolute latitude of the study location, in degrees.

alloc

Treatment-allocation method.

yi

Log risk-ratio effect-size estimate.

vi

Sampling variance of yi.

Source

van Houwelingen, H. C., Arends, L. R., & Stijnen, T. (2002). Advanced methods in meta-analysis: multivariate approach and meta-regression. Statistics in Medicine, 21(4), 589-624. The data are also distributed with the mixmeta package.

Examples

bcg
#>    trial               author year tpos  tneg cpos  cneg ablat      alloc
#> 1      1              Aronson 1948    4   119   11   128    44     random
#> 2      2     Ferguson & Simes 1949    6   300   29   274    55     random
#> 3      3      Rosenthal et al 1960    3   228   11   209    42     random
#> 4      4    Hart & Sutherland 1977   62 13536  248 12619    52     random
#> 5      5 Frimodt-Moller et al 1973   33  5036   47  5761    13  alternate
#> 6      6      Stein & Aronson 1953  180  1361  372  1079    44  alternate
#> 7      7     Vandiviere et al 1973    8  2537   10   619    19     random
#> 8      8           TPT Madras 1980  505 87886  499 87892    13     random
#> 9      9     Coetzee & Berjak 1968   29  7470   45  7232    27     random
#> 10    10      Rosenthal et al 1961   17  1699   65  1600    42 systematic
#> 11    11       Comstock et al 1974  186 50448  141 27197    18 systematic
#> 12    12   Comstock & Webster 1969    5  2493    3  2338    33 systematic
#> 13    13       Comstock et al 1976   27 16886   29 17825    33 systematic
#>             yi          vi
#> 1  -0.88931133 0.325584765
#> 2  -1.58538866 0.194581121
#> 3  -1.34807315 0.415367965
#> 4  -1.44155119 0.020010032
#> 5  -0.21754732 0.051210172
#> 6  -0.78611559 0.006905618
#> 7  -1.62089822 0.223017248
#> 8   0.01195233 0.003961579
#> 9  -0.46941765 0.056434210
#> 10 -1.37134480 0.073024794
#> 11 -0.33935883 0.012412214
#> 12  0.44591340 0.532505845
#> 13 -0.01731395 0.071404660